The Creation Relic appears in the lower floors of the Yabbashah Block in Tartarus, from the 65th to 77th floors. It is also the target of one of Elizabeth's requests, and will drop Relic Fragments until the request is completed. Five Relic Fragments are needed to complete the request.
The Creation Relic appears on the 1st through 4th floors of Marukyu Striptease within the Midnight Channel. It will attempt to affect all party member with Old One before attacking. Upon being defeated, it may drop the Hard Rock material. Selling 6 Hard Rocks at Daidara will unlock the Kozuka weapon for Yosuke Hanamura.
In Golden, the Creation Relic also drops Fluorite for trade in Shiroku Pub.