Isis was a goddess in Ancient Egyptian religious beliefs, whose worship spread throughout the Greco-Roman world. She was worshiped as the ideal mother and wife, patron of nature and magic; friend of slaves, sinners, artisans, and the downtrodden, as well as listening to the prayers of the wealthy, maidens, aristocrats and rulers.
The goddess Isis was the first daughter of Geb, god of the Earth, and Nut, the goddess of the Overarching Sky, and was born on the fourth intercalary day. Isis was said to have literally blackmailed the true name of Ra the supreme sun god out of him, by making a snake poison him, which could only be cured by Isis herself. (Ra, being a god, cannot die from the poison, but the pain would still last) In later myths about Isis, she had a brother, Osiris, who became her husband, and she then was said to have conceived Horus. Isis was instrumental in the resurrection of Osiris when he was murdered by Seth. Her magical skills restored his body to life after she gathered the body parts that had been strewn about the earth by Seth.
Isis is one of the three alignment bosses tied to the final stages of the main storyline, and was originally the Innocent Azura. After defeating her, those on the Chaos route acquire the ability to fuse her in a special triple fusion of Parvati, Thoth, and Phantom. She also appears as an enemy variant in the Ueno Mirage gold level instance. She is particularly notable for the feature she gains after mitama fusion, which allows her to drain almighty affinity at a level-based percentage.
The client in the Challenge QuestsIsis' Search for the Coffin and Osiris' Resurrection. In the first she asks for Flynn's aid on the 2nd Stratum of Naraku, stating Seth has tossed her husbands coffin into the waters that lead to Naraku and asks for Flynn to bring it to her. She thanks him when he retrieves it and will try to be wary of Seth before leaving. In the second quest she is found in Zojoji Temple at the Tokyo Tower in Roppongi. She had prepared for his husbands resurrection only for Seth to have attacked during it, tearing apart Osiris body and scattering it across Tokyo. She asks Flynn to retrieve his parts. She revives her husband after the parts are retrieved and Seth defeated . She tells Osiris it was Flynn who helped thwart Seth's schemes and plans on preparing the celebration feast at their home to celebrate his revival.
Isis is Yukari Takeba's Ultimate Persona, which Yukari acquires after learning the truth about her father and strengthening her resolve. Isis maintains the cow motif of Yukari's initial Persona, Io, as well as gaining the Headdress of Hathor.
Isis represents the bond between Yu and Margaret in Persona 4 The Animation. She was summoned after Izanagi took serious damage from Ameno-sagiri's attacks, and Yu being stuck under huge rocks. Her levitation abilities assisted Yu in getting back up once again.
She is one of the two Ultimate Personas that Yu summoned that was not created through fusion, the other being Sraosha.
Mirai Kaname / Setsuna Kai meet with her afterwards, seeking to learn what is going on. She reveals a prophecy to them about the end of the world or its rebirth, and asks that they spar with her. After the battle she gives them advice and the pieces of Sand Lands Keys of Norn. Later she can be contacted via the Devi-Phone, where she asks them to take care of another stray Sphinx she found.
Returning as the Tyrant of the reborn Earth Expanse, Isis has left Moloch in charge while she tends to other matters. Takaharu Ougi and Masaki Kuzuha both meet her to ask for a cure to the Dark Slumber. She reveals to them that the famous demon doctor Dian Cecht would have a cure, but that they must travel to the Ice Expanse to retrieve it.
Isis serves as the boss of the Green configuration of the Brutes Base in Ajna. A gimmick used during the boss fight with her is that she will respond to any element case against her during a turn by casting a single target -dyne spell of an element used back at the party. This can be used to the party's advantage by only using one type of element and having a Shield spell ready to block the retort.
Isis can also use Reiforcements to summon up to two other Isis demons. Together they will start using enemy combo elemental spells. Two Isis demons will use multi-target -dyne spells such as Maragidyne. The full group of three will use stronger elemental combos such as Trisagion.
"The mother goddess of Egypt. She is wife and sister to Osiris, god of the underworld. Known for her powerful magic, she could perform miracles such as raising her husband from the dead. As the patron goddess of the dead, her image can be found at many burial sites."
—Devil Survivor 2 Compendium
In Devil Survivor 2, Isis is a Unique demon that doesn't require a particular fusion combination to create. Instead, the player has to achieve a Fate level of 5 with Hinako Kujou before it is available. Once this has been achieved, it is unlocked for fusion on all subsequent runs as long as the player imports his/her save.
Isis is revered the ideal mother and wife as well as the patroness of nature and magic, she is also known as the protector of the dead and goddess of children. Serving as Yukari's ultimate persona in Persona 3 her titles is referenced through some of Yukari's traits, both share a love for children and an affinity for magic. Isis' role as the protector of the dead loosely ties into Yukari's role as the atoner for her decease fathers sins, striving to eliminate the Dark Hour to fulfill his final wish.
Yukari's desire to collect all the keys to the past and revive the Protagonist in "The Answer" also mimics Isis' own desire to revive her husband Osiris, by collecting his missing body parts which were scattered all around the world by the god Seth upon his defeat.
Isis appearance in Persona 3 manifesting with wings and a content smile symbolizes Yukari's new found freedom from the past after learning the truth regarding her father, renewing her will to fight. Yukari 's Isis being posed with outstretched wings is most likely a callback to the goddess Isis' original wall paintings, were she displays a similar pose.
Like how Yukari's Isis and Hathor (the wife of Isis' son Horus) share a design (Headdress) and themes (Motherly goddesses and carers of the dead) Hathor shares a similar cow motif with Yukari's initial Persona Io.