Neo Minotaur is first encountered as a boss along Path 3 of Yomotsu Hirasaka, blocking the party's way midway through the area.
This shadow will later be encountered as a regular enemy on Path 8 of the dungeon. Despite this version's high HP total for normal encounters, it takes greatly increased damage, even from Physical attacks which it resists. After being defeated, Neo Minotaurs may drop Tyrannical Hide. Selling 10 Tyrannical Hides at the TV extension of Daidara will unlock the Stella Greaves for Chie Satonaka.
Of all the bosses faced in the Abyss of Time, Neo Minotaur is the only one that is purely fought alone; the other bosses are faced in a group, and in the case of the Brilliant Cyclops and Conceited Maya, both of them are capable of summoning more Shadows to the field. Therefore, it is the only boss that is not fought in a group that is incapable of using "Summon" to bring out more Shadows.
In Persona 4, the sub-boss Neo Minotaur's information analysis mistakenly shows it as being of the Magician Arcana.