Pazuzu is the god of the southwest wind known for bringing famine during dry seasons, and locusts during rainy seasons. Recent research suggests Pazuzu may have been associated with a cold, northeasterly wind. Pazuzu was said to be invoked in amulets which combat the powers of the malicious goddess, and hated rival, Lamashtu, who was believed to cause harm to mother and child during childbirth. Although Pazuzu is, himself, an evil spirit, he drives away other evil spirits, thus protecting humans against plagues and misfortunes.
After defeating the Minotaur in the Devil Busters game, the hero finds a strange statue in the game and unseals it, revealing Pazuzu. Pazuzu reveals that he is a servant of God and that the hero and his friend are the Messiahs destined to save the world from the demons that came through a rift created during the nuclear war 35 years prior. Giving the hero a handheld computer and the Demon Summoning Program, Pazuzu warns about demons invading the shelter before departing. Once they reach the surface, Pazuzu commands that the two joins with his servant Orthrus and later sends the three to the ruins of Tokyo Tower after a witch who betrayed him. The witch reveals that Pazuzu is simply using the two to gain power over Bael and the hero agrees with her, causing the friend, who is still loyal to Pazuzu, to depart with Orthrus. It is later revealed that Pazuzu is truly aligned with God and the other demons view him as a traitor because of this. The hero and the witch end up having to defeat and behead him in order to pass onwards.
Pazuzu is the Demon Companion for Tadashi Nikaido. He can only be fused under certain conditions. This demon can be unlocked either by defeating Pazuzu before defeating Kaido on the 5th Day (if the player fails to save Keisuke Takagi from being killed by Kaido), or by initiating Naoya's ending through speaking to Kaido first.
"The evil Babylonian lord of southeastern wind and scorching sands. He has a lion's head and arms, a human body, eagle-clawed feet, bird wings, and a scorpion's tail. He also has an oddly bent horn on his forehead. It's said he comes alongside the poisonous, scorching winds from the Persian Gulf to spread plague."
Pazuzu is the leader of the Imperium forces on Jin's route. He is faced in the Dark Palace and his role is similar to Scathach. Unlike her he does not put Akira to sleep before the battle. After the battle he flees with Jin following him. The others attempt to follow as well but the doors close. He has Rand sacrificed to the seal that holds his master Belzebu and forces Jin to release him. Pazuzu is killed by his master after he is freed as he has served his purpose.