Rampage Drive is notorious since it appears early in the game, at a stage where the player is not likely to have any party members available other than Junpei Iori and Yukari Takeba. Junpei has difficulty damaging the boss since it is immune to all physical attacks and resists fire, while Yukari will face trouble if it chooses to continue to cast Mazio to keep her knocked down. Buffs and debuffs will definitely be useful in squeezing extra damage onto the boss or reducing the chances of getting hit by its troublesome attacks.
The best strategy is to level up the Pixie Persona until it learns the ability Pulinpa. This will prevent the boss from using his most powerful attacks, including Mazio, until the effect wears off. By declawing the boss in this manner he can be beaten much earlier in the game.