The Yomotsu-shikome (黄泉醜女) in Japanese mythology are residents of the underworld, or Yomi. In the myth, Izanagi, longing to be with his deceased wife Izanami, attempted to retrieve her from the Yomi. When he saw Izanami's rotten and ugly self, he ran away, and Izanami ordered the Yomotsu-Shikome, the "old hags of the Yomi" to chase after him. Izanagi slowed them down by throwing down his headdress and sacred comb, which turned into grapes and bamboo shoots respectively, and caused the Shikome to stop and eat the food, enabling Izanagi to escape the underworld.
Yomotsu Shikome appears in Digital Devil Story: Megami Tensei as a guardian to Izanami. During Akemi Nakajima's visions of the past, Yomotsu Shikome served as some sort of bodyguard to the decaying Izanami, which attacked Izanagi as he abandoned her. In the present, Yomotsu Shikome served as the tomb guardian of Izanami's tomb, deep within Shirasagi Mound. Yomotsu Shikome brutally killed anyone who entered the tomb, and she attempted to kill Nakajima when he first entered. After Yomotsu Shikome realizes Yumiko Shirasagi is the reincarnation of Izanami, she aids Nakajima by leading him deeper into the tomb and then throwing up some stones which were used to summon Hi-no-Kagutsuchi. When Loki enters the tomb, Yomotsu Shikome attempts to stop him. Loki brutally kills Yomotsu Shikome by ripping her heart out.
The Yomotsu Shikome featured in the novel is described as a disgusting, blubbery woman with a frog-like head and rancid breath. She wore a robe that was way smaller than her massive body, which could not even cover her breasts, which hung down near her stomach. This is radically different from her depiction in recent games.
"Terrifying female Oni of Japanese mythology who live in Yomi, the underworld. Yomotsu-Shikome are famous as the pursuers sent by Izanami to catch Izanagi as he fled Yomi. They were obsessed with food, so Izanagi turned his hair into wild grapes and his comb into bamboo shoots. The Yomotsu-Shikome were distracted by the food, allowing Izanagi to make his escape back to the realm of the living. Each Yomotsu-Shikome leads her own army of Yomotsu-Ikusa, their male counterparts."
—Shin Megami Tensei IMAGINE Compendium
Yomotsu-Shikome can be contracted during the day in Ueno, the new moon bronze-level instance of Shinagawa's Catacombs, the silver-level instance of Old Ichigaya Camp, and in most cars of the Old Tokyo Metro instance. She appears in boss form in the final room of Ichigaya's hacked chip instance.
"In Japanese lore, they are hideous demonesses of Yomi, the land of the dead, and serve the gods there. Izanagi came down to Yomi to take back his dead wife Izanami, but when he saw her ugly form, he tried to escape from her. Enraged, Izanami sent the Shikome after him. Each Shikome commanded an army of Yomosu Ikusa. As he ran, Izanagi threw his hair and comb to the ground. His hair became grapes and his comb bamboo sprouts. The Shikome forgot their duty and started eating them."
Shikome can be found within the Toyosu Shelter and the Konganji Passage in Ginza. She can teach the Stun Needles, Rapid Needle and Tarunda skills through her Demon Whisper. Shikome benefits from learning Gun, Darkness, and ailment skills.